PL-AMS Resin Aminomethylstyrene resin is a particularly versatile material suitable for the attachment of a variety of spacers, handles and linkers (for use in solid phase synthesis). Application: Synthesis Support
PL-Rink Resin Rink amide resins are often the support of choice for solid phase synthesis of peptide amides using Fmoc chemistry
StratoSpheres for Peptide Synthesis The StratoSpheres product line encompasses a wide range of polymer resin supports for the development and large scale manufacture of peptide APIs.
VariPure IPE is a polymer supported quaternary amine resin with a bicarbonate counter ion. It is designed for removing acidic ion-pair reagents, such as trifluoracetic acid (TFA), formic acid or acetic acid. It is a high performance and economical acid removal material conveniently supplied as pre-packed SPE type devices. The particle size, capacity and device geometry are matched to provide sufficient residence time to achieve effective ion-pair extraction under gravity flow. For acid labile peptides, removal of the ion-pairing agent prevents acid degradation of the peptide during post-HPLC work up, and increases the yield of purified product.
AmphiSpheres Specifically designed for solid phase peptide synthesis, AmphiSpheres amphipathic resin is a key product in the StratoSpheres product family. As the name suggests, this type of material contains both hydrophobic (polystyrene, PS) and hydrophilic (polyethyleneglycol, PEG) components. This subtly changes the swell characteristics of the material allowing a broader range of solvents to be used. At the same time, the active functionality is located at the end of a PEG chain which helps promote reactivity. Two versions are available with differing PEG content: – AmphiSpheres 20 has 20% w/w PEG content and a loading of 0.7 mmol/g. – AmphiSpheres 40 has 40% w/w PEG content and a loading of 0.4 mmol/g. AmphiSpheres 20 contains 20% w/w polyethylene glycol and therefore retains a high loading per gram and has handling characteristics close to that of “glassy” polystyrene. This means that the yield of product is not compromised to the same degree as with larger PEG chains. AmphiSpheres 40 contains 40% w/w polyethylene glycol and uses a longer PEG chain than AmphiSpheres 20. The amount of PEG is noticeable in that the material is more difficult to shrink down without becoming sticky. However the increased length of PEG chain can give significantly improved results in the synthesis of “difficult” peptide sequences. Attachment of the appropriate linker or handle enables the material to be used for the synthesis of peptide acids and peptide amides
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